Palmitoyl Hexapeptide-12

Irritancy: unknownComedogenicity: unknownSkin Conditioning

The details

Palmitoyl Hexapeptide-12 is a synthetic lipopeptide. This just means it's a short chain of six amino acids with a palmitic acid molecule attached to one end. The palmitoyl group increases the lipophilicity, helping it penetrate the lipid-rich outer layer of skin more effectively. Once inside, it helps with keeping skin springy and firm. It works by mimicking the skin repair signals your skin naturally sends out when it's damaged and telling it to kick into rebuild mode. Studies have shown it can help strengthen the skin barrier as well so it's useful beyond just anti-aging. In vitro studies suggest it can switch on genes that help skin cells grow, move around, and rebuild skin structure. Just keep in mind most of the strong evidence is from lab studies rather than large-scale clinical trials. Lab studies suggest it can switch on genes that help skin cells grow, move around, and rebuild skin structure. This ingredient is usually used at very low concentrations (0.002% in leave-on products). Fungal acne note: Usually a palmitic acid component can feed Malassezia in unbound form, but here is is covalently bonded to the peptide. This means it is very difficult for Malassezia to access, and therefore very unlikely to cause fungal acne.